Vaccine targetting transport of sperm

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Different carriers, namely, diphtheria toxoid DT , tetanus toxoid TT , Mycobacterium tuberculosis hsp 70 [ 13 ], thioredoxin [ 14 ], keyhole limpet hemocyanin [ 15 ], and ovalbumin, were employed. After passing these tests, next plan is to conduct clinical trials with the vaccine for preventing pregnancy, as well as for its possible therapeutic action on cancers expressing hCG or its subunits [ 35 ]. These include targeting gamete production [gonadotropin-releasing hormone GnRH , follicle-stimulating hormone FSH , and luteinizing hormone LH ], gamete function [zona pellucida ZP proteins of the oocytes and sperm antigens], and gamete outcome human chorionic gonadotropin [hCG] adapted from [ 9 ]. All the proteins have distinct conserved features such as a metalloproteinase-like domain, a disintegrin-like domain, a cysteine-rich domain, a prodomain, and a transmembrane domain also known as ADAM family [ 77 ]. In a classic study carried out in , fertile women had at least one pregnancy were injected with their husbands semen [ 55 ]. ZP is an extra cellular matrix, composed of glycoproteins, which surround the mammalian oocyte. Enhanced immunogenicity of a contraceptive vaccine using diverse synthetic carriers with permissible adjuvant.

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Immunogenicity Study Of Recombinant Human Sperm

A novel contraceptive approach that is gaining substantial attention is immunocontraception, which is the use of contraceptive vaccines CVs or preformed antibodies to prevent fertilization. The irreversibility associated with immunization using ZP posed a major hurdle in the development of ZP based contraceptive. Archives of Gynecology and Obstetrics. Contraceptive vaccines CV , especially targeting sperm-specific proteins, can provide an ideal contraceptive modality.

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Vaccine for contraception targeting sperm

Hence, an analogue of GnRH was prepared by linking with different carriers in an attempt to make improved vaccine [ 7 ]. Recombinant fertilization antigen-1 causes a contraceptive effect in actively immunized mice. The results suggested that this antigen was produced by germ cells during spermatogenesis. Is FSH required for adult spermatogenesis. Vaccination of boars with a GnRH vaccine Improvac eliminates boar taint and increases growth performance.

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Description: Both the peptides were used in monomeric as well as dimeric form tandem and were subsequently used to immunize male rabbits, respectively. Sperm has both auto- and isoantigens and hence immunization of several species of animals and humans with sperm results in generation of antisperm antibodies ASA , leading to infertility [ 54 ]. Decreased fertilization rates were observed in male rats, after immunization with purified DE. Immunization of male mice with peptide1 resulted in production of specific antibodies. After this destabilization, calpain could trigger the premature sperm acrosome reaction before sperm would reach the ovum, thus resulting in deterioration of the sperm fertilizing capability. Therefore, it can be concluded that interaction of bacterium with spermatozoa is receptor mediated and involves interplay of multiple factors which cumulatively lead to sperm damage.
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