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However, healthcare providers must consider the balance between benefits and risks of tibolone, as concerns have arisen about breast and endometrial cancer and stroke. Most studies evaluated tibolone for treatment of menopausal vasomotor symptoms. Compared with placebo , tibolone increases the risk of recurrent breast cancer in women with a history of breast cancer, and may increase the risk of stroke in women over 60 years of age. Background Tibolone is an available option for the treatment of menopausal symptoms, and short-term data suggest its efficacy.

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Tibolone As Menopausal Hormone Therapy

To evaluate the effectiveness and safety of tibolone for treatment of postmenopausal and perimenopausal women. Tibolone versus placebo Vasomotor symptoms Tibolone was more effective than placebo standard mean difference SMD Cochrane review authors aimed to evaluate the effectiveness and safety of tibolone for treatment of postmenopausal and perimenopausal women. We checked the reference lists in articles retrieved. Most studies were financed by drug manufacturers or failed to disclose their funding source. Much of the evidence obtained was of low or very low quality.

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Livial and its tissue specific effects on breast tissue

Twenty-six of the studies were financed by drug manufacturers, and another 14 studies failed to disclose their source of funding. Study characteristics We included 46 randomised controlled trials RCTs , which included 19, postmenopausal women. Most studies reporting these outcomes provided follow-up of two to three years range three months to three years. Limitations included high risk of bias in the included trials, very low event rates and potential conflicts of interest. Unscheduled bleeding Tibolone was associated with greater likelihood of bleeding OR 2. Tibolone was associated with a lower rate of bleeding OR 0. We evaluated safety outcomes and bleeding in studies including women either with or without menopausal symptoms.

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Description: We found no conclusive evidence of differences between groups in cerebrovascular events OR 1. You may also be interested in. Quality of the evidence Much of the evidence obtained was of low or very low quality. Short-term and long-term effects of tibolone in postmenopausal women Review question Cochrane review authors aimed to evaluate the effectiveness and safety of tibolone for treatment of postmenopausal and perimenopausal women. Compared with placebo , tibolone increases recurrent breast cancer rates in women with a history of breast cancer, and may increase stroke rates in women over 60 years of age. Tibolone was associated with a lower rate of bleeding OR 0. Moderate-quality evidence suggests that tibolone is more effective than placebo but less effective than HT in reducing menopausal vasomotor symptoms, and that tibolone is associated with a higher rate of unscheduled bleeding than placebo but with a lower rate than HT.
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